Artificial repressors for controlling gene expression in bacteria.
نویسندگان
چکیده
Transcriptional repression is a common approach to control gene expression in synthetic biology applications. Here, an engineered DNA binding protein based upon a transcription activator-like effector (TALE) scaffold was shown to outperform LacI in blocking transcription from a promoter and to repress expression of a downstream gene in an operon.
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عنوان ژورنال:
- Chemical communications
دوره 49 39 شماره
صفحات -
تاریخ انتشار 2013